Effects of atorvastatin and metformin on development of pentylenetetrazole-induced seizure in mice
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Acute and Chronic Effects of N-acetylcysteine on Pentylenetetrazole-induced Seizure and Neuromuscular Coordination in Mice
Background: N-acetylcysteine (NAC) has been indicated against experimental seizures, but with relatively inconclusive results. This study was undertaken to evaluate whether NAC exerts a dose-dependent anticonvulsant effect and to determine NAC safe therapeutic dose range and its muscle-relaxant activity in both acute and chronic uses.Methods: Following intraperitoneal (i.p.) administration of N...
متن کاملacute and chronic effects of n-acetylcysteine on pentylenetetrazole-induced seizure and neuromuscular coordination in mice
background: n-acetylcysteine (nac) has been indicated against experimental seizures, but with relatively inconclusive results. this study was undertaken to evaluate whether nac exerts a dose-dependent anticonvulsant effect and to determine nac safe therapeutic dose range and its muscle-relaxant activity in both acute and chronic uses. methods: following intraperitoneal (i.p.) administration of ...
متن کاملCopper sulfate inhibits seizure activity induced by pentylenetetrazole in mice
Background and Objective: Copper is one of the main micronutrients of body which plays a key role as a cofactor in the function of metabolic enzymes. Previous studies have shown that copper sulfate () inhibits long-term potentiation (LTP) in slices of hippocampal CA1 region. Whereas LTP is involved in learning and epilepsy, it seems that copper effects on LTP could be associated with its effect...
متن کاملThe Effects of Hydro-alcoholic Extract of Ocimum Basilicum Green Leaf on Pentylenetetrazole-induced Seizure in Male Mice
Background: Regarding the chronic nature of epilepsy, and drug resistance in many cases, herbal medicine has received remarkable interest. Objective The present study aimed to determine the anticonvulsant effects of hydro-alcoholic extract of Ocimum basilicum green leaf on Pentylenetetrazole (PTZ)-induced seizure in male mice. Methods: In this experimental study, 48 albino male mice, weighin...
متن کاملEffect of mobile phone radiation on pentylenetetrazole-induced seizure threshold in mice
Objective(s): Scientific interest in potential mobile phone impact on human brain and performance has significantly increased in recent years. The present study was designed to evaluate the effects of mobile phone radiation on seizure threshold in mice. Materials and methods:BALB/c male mice were randomly divided into three groups: control, acute, and chronic mobile phone radiation for 30, 60, ...
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ژورنال
عنوان ژورنال: Heliyon
سال: 2020
ISSN: 2405-8440
DOI: 10.1016/j.heliyon.2020.e03761